AbbVie’s Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas.
Responsibilities:
- Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
- Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation.
- Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs.
- Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field.
- Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement.
- Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals.